Deca-Durabolin (Nandrolone Decanoate)

Deca-Durabolin effect

Nandrolone Decanoate is an injectable form of the anabolic steroid Nandrolone. The decanoate ester provides a slow, up to three weeks, release of Nandrolone from the injection site. Nandrolone is very similar in structure to testosterone, although it lacks a carbon atom at the 19th position (hence its other name, 19-nortestosterone). Like testosterone, Nandrolone is a relatively strong anabolic. However, unlike testosterone, Nandrolone has weak androgenic characteristics.

Nandrolone converts to the weak steroid dihydronandrolone, in the same androgen-responsive target tissues that increase the action of testosterone (converting it to dihydrotestosterone, or DHT). The mild properties of Nandrolone Decanoate have made it one of the most popular injectable steroids worldwide, prized by athletes for its ability to induce significant gains in strength and muscle mass without strong androgenic or estrogenic side effects. Read more here


Nandrolone decanoate was first described in 1960, and already in 1962 it became a prescription drug. The drug was developed by the pharmaceutical giant Organon and sold under the brand name Deca-Durabolin. The name Deca means that the product is a variant of the previously popular injectable product Nandrolone Durabolin (Nandrolone phenylpropionate), using an ester on 10 carbon atoms. Soon after the drug was created, Organon launched Nandrolone Decanoate on the market.

Thanks to the combination of the beneficial properties of the drug and the widespread popularity of Organon in the market, Deca-Durabolin soon becomes one of the most widely used anabolic steroids in the world. When the drug was first released in the United States, Nandrolone Decanoate (called Durabolin) was prescribed as a medicine for various ailments. Indications for use included pre- and postoperative use to increase muscle mass.

The drug has also been prescribed for diseases such as osteoporosis, advanced breast cancer, weight loss due to recovery or illness, geriatric disorders (general weakness and fragility of the body), burns, severe trauma, ulcers, as well as for adjuvant therapy for certain forms of anemia , and selective cases of lack of growth and development in children. The drug was initially sold at dosages of only 50 mg / ml due to the very low recommended doses (usually 50-100 mg every 3-4 weeks).

Deca-Durabolin side effects (estrogenic)

Nandrolone is little converted to estrogen (the conversion rate is only about 20% of the conversion of testosterone). Although the liver can convert nandrolone to estradiol, in other, more active areas of steroid aromatization, such as adipose tissue, nandrolone is much less open to such processes. Consequently, estrogenic side effects are much less common with this substance than with testosterone. At higher dosages, an increase in estrogen levels can be observed, causing side effects such as increased water retention, fat deposition, and gynecomastia.

An anti-estrogen, such as clomiphene citrate or tamoxifen citrate, may be required to prevent the estrogenic side effects that occur. Alternatively, aromatase inhibitors such as Arimidex® (Anastrozole) can be used to better control estrogen levels by preventing estrogen synthesis. Aromatase inhibitors can seem quite expensive compared to anti-estrogens, and can also have negative effects on blood lipids.

Side effects (androgenic)

Although the steroid is classified as an anabolic steroid, androgenic side effects are common with this substance and may include symptoms such as increased sebaceous glands, acne, and body / facial hair growth.

Anabolic / androgenic steroids can also worsen male pattern baldness. Women should be aware of the potential virilizing effects of anabolic / androgenic steroids. These can include: deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with a relatively low relative tissue androgenic activity, which makes the threshold for severe androgenic side effects relatively higher than that of more androgenic compounds such as testosterone, methandrostenolone, or fluoxymesterone.

It is also important to note that due to its mild androgenic nature and its ability to suppress endogenous testosterone production, Nandrolone can affect libido in men in the absence of other androgens. Note that in androgen-responsive target tissues such as skin, scalp, and prostate, the relative androgenicity of Nandrolone decreases when reduced to dihydroNandrolone. The 5-alpha-reductase enzyme is responsible for this metabolism of Nandrolone.

Concomitant use of 5-alpha reductase inhibitors such as finasteride or dutasteride affects the local recovery of nandrolone, significantly increasing its tendency to produce androgenic side effects. If the user wishes to achieve a reduced androgenic level, the use of reductase inhibitors should be avoided.

Deca-Durabolin course (men)

  • To achieve a general anabolic effect, the initial recommendations for the use of the drug recommended doses of 50-100 mg every 3-4 weeks for 12 weeks. For the treatment of renal anemia, the recommended dose was 100-200 mg per week. The usual dosage for athletic purposes is in the range of 200-600 mg per week, on cycles of 8 to 12 weeks. This level is sufficient for measurable gains in muscle mass and strength for most users.
  • It is often claimed that Nandrolone Decanoate has the maximum effect (best benefit / side effect ratio) at doses of 2 mg per kg of body weight weekly, although this dosage is likely to be influenced by individual user differences. Deca is not a very fast muscle builder. The muscle building effect of this drug is quite noticeable, but not very rapid. Overall, the drug is about half as effective as testosterone.
  • To enhance the effect, Nandrolone Decanoate is often combined with other steroids. When combined with Nandrolone decanoate at a dose of 200-400 mg per week and Winstrol at a dose of 10-20 mg daily, there is a significant improvement in the appearance of the muscles and an increase in relief during diet / drying. Strong non-aromatizing androgens such as Halotestin® or Trenbolone can also be used to provide increased levels of muscle hardness and density.

As a moderately strong muscle builder, Nandrolone can also be incorporated into weight gain cycles. The classic combination of Deca and D-Bal (typically 200-400 mg Nandrolone Decanoate per week and 15-25 mg Dianabol per day) has been a staple in bodybuilding for decades, and has been shown to provide significant muscle gains. Stronger androgens such as Anadrol 50® or testosterone can also be used, but they will have greater water retention when used.

Deca-Durabolin course (women)

To achieve a general anabolic effect, the initial guidelines for prescribing the drug recommended doses of 50-100 mg every 3-4 weeks for 12 weeks. For the treatment of renal anemia, the Nandrolone Decanoate guideline recommends doses of 50-100 mg per week.

When used for athletic purposes, the most common dosage is 50 mg per week, which is applied for 4-6 weeks. Although the drug is a mild androgen, women may still experience virilization symptoms when taking this compound.

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